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1

An analysis of the attrition of drug candidates from four major pharmaceutical companies

Waring, Michael J., Arrowsmith, John, Leach, Andrew R., Leeson, Paul D., Mandrell, Sam, Owen, Robert M., Pairaudeau, Garry, Pennie, William D., Pickett, Stephen D., Wang, Jibo, Wallace, Owen, Weir, Al

Journal:

Nature Reviews Drug Discovery

Année:

2015

Langue:

english

Fichier:

PDF, 435 KB

english, 2015

2

Hypothesis: Multiple Sclerosis is caused by three-hits, strictly in order, in genetically susceptible persons

Kearns, Patrick K A, Casey, Helen A, Leach, John Paul

Journal:

Multiple Sclerosis and Related Disorders

Année:

2018

Langue:

english

Fichier:

PDF, 1.37 MB

english, 2018

3

Measurement of the extracellular pH of solid tumours in mice by magnetic resonance spectroscopy: a comparison of exogenous 19F and 31P probes

Agatha S. E. Ojugo, Paul M. J. McSheehy, Dominick J. O. McIntyre, Cheryl McCoy, Marion Stubbs, Martin O. Leach, Ian R. Judson, John R. Griffiths

Journal:

NMR in Biomedicine

Année:

1999

Langue:

english

Fichier:

PDF, 288 KB

english, 1999

4

Sodium valproate versus lamotrigine: A randomised comparison of efficacy, tolerability and effects on circulating androgenic hormones in newly diagnosed epilepsy

Linda J. Stephen, Graeme J. Sills, John Paul Leach, Elaine Butler, Pamela Parker, Nikolas Hitiris, Veronica M. Leach, Elaine A. Wilson, Martin J. Brodie

Journal:

Epilepsy Research

Année:

2007

Langue:

english

Fichier:

PDF, 582 KB

english, 2007

5

Behavioural effects of ovariohysterectomy and oral administration of meloxicam in laboratory housed rabbits

Matthew C. Leach, Sandra Allweiler, Claire Richardson, John V. Roughan, Ruediger Narbe, Paul A. Flecknell

Journal:

Research in Veterinary Science

Année:

2009

Langue:

english

Fichier:

PDF, 502 KB

english, 2009

6

Accelerated long-term forgetting in temporal lobe epilepsy: Verbal, nonverbal and autobiographical memory

Narayanan, Jwala, Duncan, Rod, Greene, John, Leach, John-Paul, Razvi, Saif, McLean, John, Evans, Jonathan J.

Journal:

Epilepsy & Behavior

Année:

2012

Langue:

english

Fichier:

PDF, 443 KB

english, 2012

7

Meningitis presenting as spontaneous subarachnoid haemorrhage (pseudo-subarachnoid haemorrhage)

Lang, Jozsef Lorant, Leach, Paul L., Emelifeonwu, John A., Bukhari, Safquat

Journal:

European Journal of Emergency Medicine

Année:

2013

Langue:

english

Fichier:

PDF, 126 KB

english, 2013

8

Biomass for thermochemical conversion: targets and challenges

Tanger, Paul, Field, John L., Jahn, Courtney E., DeFoort, Morgan W., Leach, Jan E.

Journal:

Frontiers in Plant Science

Année:

2013

Langue:

english

Fichier:

PDF, 863 KB

english, 2013

9

Non-synostotic posterior brachycephaly with hindbrain herniation

Pathmanaban, Omar N., Burke, Kerry A., Leach, Paul, Thorne, John, Kamaly-Asl, Ian D.

Journal:

World Neurosurgery

Année:

2016

Langue:

english

Fichier:

PDF, 968 KB

english, 2016

10

SUDEP, the aftermath: supporting the bereaved

Nashef, Lina, Leach, John Paul

Journal:

Practical Neurology

Année:

2017

Langue:

english

Fichier:

PDF, 192 KB

english, 2017

11

Transforming Innovation for Sustainability

Leach, Melissa, Rockström, Johan, Raskin, Paul, Scoones, Ian, Stirling, Andy C., Smith, Adrian, Thompson, John, Millstone, Erik, Ely, Adrian, Arond, Elisa, Folke, Carl, Olsson, Per

Journal:

Ecology and Society

Année:

2012

Langue:

english

Fichier:

PDF, 49 KB

english, 2012

12

Refractory status epilepticus in adults admitted to ITU in Glasgow 1995–2013 a longitudinal audit highlighting the need for action for provoked and unprovoked status epilepticus

Abbasi, Hinanaz, Leach, John Paul

Journal:

Année:

2019

Fichier:

PDF, 408 KB

2019

13

Differential expression of the mismatch repair gene hMSH2 in malignant prostate tissue is associated with cancer recurrence

Alfredo Velasco, Stephen M. Hewitt, Paul S. Albert, M. Hossein Saboorian, Helmar Rosenberg, Carlos Martinez, Arthur I. Sagalowsky, John D. McConnell, W. Marston Linehan, Fredrick S. Leach

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 791 KB

english, 2002

14

In vivo hyperpolarized 129Xe NMR spectroscopy in tumors

Jan Wolber, Dominick J.O. McIntyre, Loreta M. Rodrigues, Paul Carnochan, John R. Griffiths, Martin O. Leach, Angelo Bifone

Journal:

Magnetic Resonance in Medicine

Année:

2001

Langue:

english

Fichier:

PDF, 586 KB

english, 2001

15

Determination of gabapentin in plasma by high-performance liquid chromatography

Gerard Forrest, Graeme J. Sills, John Paul Leach, Martin J. Brodie

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Année:

1996

Langue:

english

Fichier:

PDF, 307 KB

english, 1996

16

Response to drug treatment in newly diagnosed epilepsy: A pilot study of 1H NMR- and MS-based metabonomic analysis

Muhammed Al Zweiri, Graeme J. Sills, John Paul Leach, Martin J. Brodie, Chris Robertson, David G. Watson, John A. Parkinson

Journal:

Epilepsy Research

Année:

2010

Langue:

english

Fichier:

PDF, 486 KB

english, 2010

17

Mutual interaction between remacemide hydrochloride and phenytoin

John Paul Leach, Jacqueline Girvan, Virginia Jamieson, Tracey Jones, Alan Richens, Martin J Brodie

Journal:

Epilepsy Research

Année:

1997

Langue:

english

Fichier:

PDF, 255 KB

english, 1997

18

Neurochemical actions of gabapentin in mouse brain

John Paul Leach, Graeme J Sills, Elaine Butler, Gerard Forrest, George G Thompson, Martin J Brodie

Journal:

Epilepsy Research

Année:

1997

Langue:

english

Fichier:

PDF, 407 KB

english, 1997

19

New Antieplieptic Drugs - Revolution or Marketing Spin?

John Paul Leach, Tony Marson, David Chadwick

Journal:

Practical Neurology

Année:

2001

Langue:

english

Fichier:

PDF, 458 KB

english, 2001

20

Unsual penetrating cranio-cerebral injuries in children from main plugs

Paul Leach, John Thorne

Journal:

Child's Nervous System

Année:

2008

Langue:

english

Fichier:

PDF, 43 KB

english, 2008

21

Misdiagnosed shoulder tip pain: complication of a ventriculoperitoneal shunt

Jozsef Lorant Lang, John Amaechi Emelifeonwu, Richard Herford Hatfield, Paul Leach

Journal:

Acta Neurochirurgica

Année:

2011

Langue:

english

Fichier:

PDF, 99 KB

english, 2011

22

Neurochemical actions of the desglycinyl metabolite of remacemide hydrochloride (ARL 12495AA) in mouse brain

John Paul Leach, Graeme J Sills, Elaine Butler, Gerard Forrest, George G Thompson, Martin J Brodie

Journal:

British Journal of Pharmacology

Année:

1997

Langue:

english

Fichier:

PDF, 282 KB

english, 1997

23

Can a patient-centred approach to epilepsy improve outcomes?

Ley Sander, Ann Jacoby, John Paul Leach

Journal:

Progress in Neurology and Psychiatry

Année:

2010

Langue:

english

Fichier:

PDF, 101 KB

english, 2010

24

A comparison of a manual and an automated behavioural analysis method for assessing post-operative pain in mice

Amy L. Miller, Paul A. Flecknell, Matthew C. Leach, John V. Roughan

Journal:

Applied Animal Behaviour Science

Année:

2011

Langue:

english

Fichier:

PDF, 495 KB

english, 2011

25

Neurochemical actions of vigabatrin and tiagabine alone and in combination in mouse cortex

John Paul Leach, Graeme J. Sills, Elaine Butler, Gerard Forrest, George G. Thompson, Martin J. Brodie

Journal:

General Pharmacology: The Vascular System

Année:

1997

Langue:

english

Fichier:

PDF, 557 KB

english, 1997

26

Mutual Interaction Between Remacemide Hydrochloride and Carbamazepine: Two Drugs with Active Metabolites

John Paul Leach, Jackie Blacklaw, Virginia Jamieson, Tracey Jones, Alan Richens, Martin J. Brodie

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 656 KB

english, 1996

27

Tiagabine

John Paul Leach, Martin J Brodie

Journal:

Année:

1998

Langue:

english

Fichier:

PDF, 97 KB

english, 1998

28

New antiepileptic drugs—an explosion of activity

John Paul Leach, Martin J. Brodie

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 1.05 MB

english, 1995

29

Effects of tiagabine and vigabatrin on GABA uptake into primary cultures of rat cortical astrocytes

John Paul Leach, Graeme J. Sills, Arshad Majid, Elaine Butler, Andrew Carswell, George G. Thompson, Martin J. Brodie

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 585 KB

english, 1996

30

REVIEW Antiepileptic drugs: safety in numbers?

John Paul Leach

Journal:

Année:

2000

Langue:

english

Fichier:

PDF, 144 KB

english, 2000

31

Alcohol and drugs in epilepsy: Pathophysiology, presentation, possibilities, and prevention

John Paul Leach, Rajiv Mohanraj, William Borland

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 113 KB

english, 2012

32

Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain

Graeme J. Sills, John Paul Leach, Caroline M. Fraser, Gerard Forrest, Philip N. Patsalos, Martin J. Brodie

Journal:

European Journal of Pharmacology

Année:

1997

Langue:

english

Fichier:

PDF, 184 KB

english, 1997

33

Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy

Loreta M Rodrigues, Yuen-Li Chung, Nada M S Al Saffar, Swee Y Sharp, Laura E Jackson, Udai Banerji, Marion Stubbs, Martin O Leach, John R Griffiths, Paul Workman

Journal:

BMC Research Notes

Année:

2012

Langue:

english

Fichier:

PDF, 411 KB

english, 2012

34

Noninvasive Magnetic Resonance Spectroscopic Pharmacodynamic Markers of a Novel Histone Deacetylase Inhibitor, LAQ824, in Human Colon Carcinoma Cells and Xenografts

Chung, Yuen-Li, Troy, Helen, Kristeleit, Rebecca, Aherne, Wynne, Jackson, L. Elizabeth, Atadja, Peter, Griffiths, John R., Judson, Ian R., Workman, Paul, Leach, Martin O., Beloueche-Babari, Mounia

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 624 KB

english, 2008

35

The Year's Work in Folk Song and Dance

A. H. S., Pullen Jackson, MacEdward Leach, Paul G. Brewster, Henri Naef, Ruth Harvey, Richard Callender and John Bremer

Journal:

Journal of the English Folk Dance and Song Society

Année:

1947

Langue:

english

Fichier:

PDF, 371 KB

english, 1947

36

Creating permanent 3D arrangements of isolated cells using holographic optical tweezers

Jordan, Pamela, Leach, Jonathan, Padgett, Miles, Blackburn, Paul, Isaacs, Neil, Goksör, Mattias, Hanstorp, Dag, Wright, Amanda, Girkin, John, Cooper, Jonathan

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 353 KB

english, 2005

37

Polypharmacy with Anticonvulsants

Dr John Paul Leach

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 1.65 MB

english, 1997

38

Future Prospects for the Drug Treatment of Epilepsy

Andrew Nicolson,Dr John Paul Leach

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 184 KB

english, 2001

39

Assessing the benefits and risks of stopping antiepileptic drugs

Gallagher, Paul, Leach, John Paul

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2013

40

[IEEE 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Chicago, IL (2014.8.26-2014.8.30)] 2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Electrically stimulated signals from a long-term Regenerative Peripheral Nerve Interface

Langhals, Nicholas B., Woo, Shoshana L., Moon, Jana D., Larson, John V., Leach, Michelle K., Cederna, Paul S., Urbanchek, Melanie G.

Année:

2014

Langue:

english

Fichier:

PDF, 953 KB

english, 2014

41

Cochrane Database of Systematic Reviews (Reviews) || Remacemide for drug-resistant localization related epilepsy

Leach, John Paul

Année:

1996

Langue:

english

Fichier:

PDF, 168 KB

english, 1996

42

Death in pregnancy: a call for neurological action

Leach, John Paul

Journal:

Practical Neurology

Année:

2015

Langue:

english

Fichier:

PDF, 101 KB

english, 2015

43

BOOK REVIEWS

Kresl, Peter Karl, Aubery, Pierre, Hawks, Graham P., Johnson, Arthur, Leach, Richard, Galbraith, John S., Preston, Richard A., Young, Brian, Ferres, John, Meldrum, Ronald M., Holsinger, M. Paul, Chart

Journal:

The American Review of Canadian Studies

Année:

1978

Langue:

english

Fichier:

PDF, 2.06 MB

english, 1978

44

Response to: Ten Years of Experience with Paediatric Neuroendoscopic Third Ventriculostomy Features and Perioperative Complications of 210 Cases

Leach, Paul, Thorne, John, Palmer, James

Journal:

Journal of Neurosurgical Anesthesiology

Année:

2005

Langue:

english

Fichier:

PDF, 227 KB

english, 2005

45

Secondary Reconstruction of the Lateral Ligaments of the Ankle

LEACH, ROBERT E., NAMIKI, OSAMU, PAUL, G. RICHARD, STOCKEL, JOHN

Journal:

Clinical Orthopaedics and Related Research®

Année:

1981

Langue:

english

Fichier:

PDF, 2.72 MB

english, 1981

46

Common ABCB1 polymorphisms are not associated with multidrug resistance in epilepsy using a gene-wide tagging approach

Leschziner, Guy D., Andrew, Toby, Leach, John Paul, Chadwick, David, Coffey, Alison J., Balding, David J., Bentley, David R., Pirmohamed, Munir, Johnson, Michael R.

Journal:

Pharmacogenetics and Genomics

Année:

2007

Langue:

english

Fichier:

PDF, 73 KB

english, 2007

47

On the role of visualisation in fisheries management

Levontin, Polina, Baranowski, Paul, Leach, Adrian W., Bailey, Alexandria, Mumford, John D., Quetglas, Antoni, Kell, Laurence T.

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2017

48

Characterization of the Xanthomonas translucens Complex Using Draft Genomes, Comparative Genomics, Phylogenetic Analysis, and Diagnostic LAMP Assays

Langlois, Paul A., Snelling, Jacob, Hamilton, John P., Bragard, Claude, Koebnik, Ralf, Verdier, Valérie, Triplett, Lindsay R., Blom, Jochen, Tisserat, Ned A., Leach, Jan E.

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 2.84 MB

english, 2017

49

Moving beyond the MSY concept to reflect multidimensional fisheries management objectives

Rindorf, Anna, Mumford, John, Baranowski, Paul, Clausen, Lotte Worsøe, García, Dorleta, Hintzen, Niels T., Kempf, Alexander, Leach, Adrian, Levontin, Polina, Mace, Pamela, Mackinson, Steven, Maravelia

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 670 KB

english, 2017

50

RETROSPECTIVE STUDY OF STATUS EPILEPTICUS IN ADULTS IN GLASGOW FROM 1996–2013

Abbasi, Hina, Leach, John Paul

Journal:

Journal of Neurology Neurosurgery & Psychiatry

Année:

2016

Langue:

english

Fichier:

PDF, 57 KB

english, 2016